The aim of our research is to understand how cell populations cope with and adapt to environmental change. We investigate this question across several levels of biological organization, from single genes, to cellular networks, to cell populations. A core focus of our lab is the continuing development of high-throughput technologies that track large numbers of cell lineages in competing populations to determine their relative fitnesses and evolutionary trajectories. In collaboration with theorists, we use these measurements to quantitatively describe the adaptive process of large populations with the goal of eventually deriving a predictive theory of adaptation. We are also using these technologies to study how environmental fluctuations shape evolutionary strategies, how genetic and protein-protein interaction networks change across environments, and how genetic architecture constrains the adaptive process.
We currently have openings for motivated postdocs and graduate students. We hope to form a vibrant interdisciplinary group of researchers focused on developing quantitative methods to answer long-standing biological questions. Interested applicants should contact Sasha Levy.